Influenza HA-reactive antibodies

This image depicts epitopes on one of the major surface proteins on the influenza virus, hemagglutinin (HA). It highlights a paper published in the Journal of Virology: Vol 93, issue 21, in which the Wilson laboratory compared two types of current seasonal influenza vaccine: Flublok (a recombinant HA vaccine) and Flucelvax (a mammalian cell grown vaccine). The results show these two vaccines are similarly immunogenic but may differ in the preferences of the elicited antibodies toward the receptor-binding domain on the HA head (yellow-colored on the picture). The frequency of antibodies targeting conserved epitopes on the HA stalk domain (white-colored) was similar between both vaccines.